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Principal Axis Transform

Key Investigators


Project Description

Current slicer modules for general registration (BRAINs or Elastix) are unable to handle large initial mismatch between the two objects of interest. The purpose of this project is to create a slicer module that would allow registering two volumes with large initial mismatches (>15-20 degs) based on their principal axes. The module would also come with the capability for allowing users to visualize the volumes (as a model) and the direction of the principal vectors.


  1. Implement algorithm for performing principal axis transformation.
  2. Implement visualization tools.

Approach and Plan

  1. Load the CT scans
  2. Threshold the scans
  3. Find the inertial matrices associated with the two volumes
  4. Obtain the eigen vectors associated with the inertial matrices
  5. Calculate the transformation matrix
  6. Create models from the the initial scans
  7. Transform the center of the model to the world origin
  8. Apply the transform obtained from #5
  9. Create ruler annotations for visualizing the vectors and applying appropriate transformations (from #7 then #5)

Progress and Next Steps

The approach listed above was implemented but there are a few bugs, potentially due to the coordinate system mismatch between slicer/numpy/vtk. The goal during this week is to fix these and optimize the module.

End results:

Future improvements:


At the beginning of the week, the volumes look like this: In this picture, the color green is associated with the fixed volume and yellow is associated with the moving volume. The goal is to match the position and orientation of the moving to the fixed volume. The green lines represent the principal directions of the volume and as you can see, they don't look like they are pointing in the right directions.

After the project week, the same volumes in the image above look like this: Result by the end of the week.

Progress on analysis:

spherical approximation.

Background and References

paper: http://jnm.snmjournals.org/content/31/10/1717.full.pdf